Biodegradable Poly (dl-lactide-co-glycolide) Microcapsules as a Drug Delivery System

الموضوعات

علوم بحتة وطبيعية

الملخص

Poly dl-lactide co-glycolide (PLG) is a biodegradable polymer that has a slow degradation rate and high permeability to small drug molecules.PLG microcapsules were prepared by emulsifying a polymer solution that consists of PLG/solvent (dichloromethane) into a continuous phase that consists of a nonsolvent solution (water and SDS as a surfactant). After emulsification, the solvent diffuses out of polymer droplets (liquid microcapsules) to the nonsolvent solution and then evaporates at the surface of the nonsolvent to the air. The encapsulation of the limonene within the polymer microcapsules was prepared, and limonene release was determined with time from polymer microcapsules prepared.The current study aims at studying the effect of the type of the nonsolvnet on the drug release behavior (i.e. kinetics) out of the microcapsules in relation with the properties of the polymer shell.The drug release from the solid microcapsules was measured using spectroscopic techniques. The size of microcapsules was analyzed by optical light microscope.The PLG microcapsules were prepared by emulsifying the polymer solution in continuous phase. The two phases were mixed for at least 2 hr using a magnetic stirrer; the size of prepared microcapsules was measured by the light microscope.The PLG microcapsules were prepared using different concentrations of SDS solution, methanol, and ethanol and study of its impact on the size of the PLG microcapsules.Our results show that as the concentration of nonsolvent increases in the process of preparing of PLG microcapsules the size of prepared microcapsules decreases and the limonene release increases from polymer microcapsules with decreasing the size of microcapsules.These results can be explained as follows: with increasing the concentration of methanol, ethanol or SDS, the viscosity of the nonsolvent increases and the interfacial tension decreases. This lead to a decrease in size of obtained PLG microcapsules and smaller microcapsules are obtained.

روابط وملفات

التعريف والنوع

رقم الوثيقة

0547b35e-1af8-4146-bd31-48e0a956f7b9

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

47770_1.pdf

بيانات النشر

ترجمة العنوان

كريات مبلمر دل -لاكتايد كو -جلايكولايد القابل للتحليل الحيوي ككبسولات لتفريغ الدواء

ألقاب المؤلفين

[{"name_ar":" محمد سليمان","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"حسن صوالحه","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"يونس عبد يونس ابو عين","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Biodegradable Poly (dl-lactide-co-glycolide) Microcapsules as a Drug Delivery System

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

محمد سليمان, حسن صوالحه

الإعداد

يونس عبد يونس ابو عين

الاقتباسات الببليوغرافية