Effect of Sodium Cromoglycate in Sudanese patients with Vernal Keratoconjunctivitis

الموضوعات

طب

الملخص

Vernal keratoconjunctivitis (VKC) is an allergic conditionwhich predominantly affects male children and young adults. VKCvictims may suffer from symptoms throughout the year, but theintensity of signs and symptoms increases during the hotseasons. Mast cells appear to play an important role in thepathogenesis of VKC.Objective:This study aims to evaluate from a clinical point of view therole of sodium cromoglycate in the treatment of VKC.Methods:In a single masked interventional study, done in MakkahEye Complex in Khartoum state during the period Jan – June2004, 97 patients with vernal keratoconjunctivitis were included inthis study, 68 patients were the study group using sodiumcromoglycate eye drops and 29 patients were the control groupusing tears naturale as a placebo.A questionnaire designed containing all necessaryinformation was completed and full ocular examination for eachpatient was performed. Signs and symptoms were graded andrecorded in three stages: stage 1(baseline examination), stage 2(after 2 weeks) and stage 3 (after 4 weeks). Treatments weregiven to the patients as follows: first two weeks steroids plussodium cromoglycate for the study group and steroid plus placebofor the control group. At the end of the first 2 weeks steroidstopped and treatment continued with sodium cromoglycate forthe study group and placebo for the control group for 4 weeks.Results:Itching and hyperaemia were the main presenting symptomand sign of VKC. In the first follow up there was improvement insymptoms and signs of both study and control groups and thiswas attributed to the anti-inflammatory effect of steroid.In the second follow up there was a significant improvementin the symptoms and signs among the study group and this wasattributed to the mast cell stabilization effect of sodiumcromoglycate while in the control group the improvement was notsignificant, and some symptoms and signs were getting worse.Conclusion:Sodium cromoglycate is effective as a prophylactic drug inthe treatment of VKC.

روابط وملفات

التعريف والنوع

رقم الوثيقة

05168125-057d-421c-b2f0-53fcce162495

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1639253_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"اميرة رافعي","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"عبدالرحمن دياب","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Effect of Sodium Cromoglycate in Sudanese patients with Vernal Keratoconjunctivitis

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

عبدالرحمن دياب

الإعداد

اميرة رافعي

الاقتباسات الببليوغرافية