BREATH-BASED DETECTION OF LIVER CANCER BIOMARKERS USING AN SWCNT-FET NANO-BIOSENSOR: QUANTUMATK

الموضوعات

علوم تطبيقية وتكنولوجية

الملخص

Early detection of liver cancer remains limited by the slow pace and invasiveness of current testing methods. This study proposes a single-walled carbon nanotube field-effect transistor (SWCNT-FET) designed to detect hexanal—a volatile organic compound (VOC) elevated in liver cancer—directly from exhaled breath. The device is modeled in Quantum ATK using a semi-empirical Extended Hückel Hamiltonian within the non-equilibrium Green's function (NEGF) framework, emphasizing realistic contact physics by employing metallic SWCNT electrodes instead of conventional metal films. Zigzag channels with (11,0) and (12,0) chiralities are examined to analyze how geometry and contact matching influence charge transport. Simulations include current–voltage (I–V) characteristics and transmission spectra under gate biases from 0 to 2 V, with particular focus on an operating point at 1.4 V. Upon hexanal adsorption, the device shows a consistent conductance quench and the emergence of anti-resonances near the Fermi level. Among the tested configurations, the (11,0) channel paired with metallic SWCNT contacts exhibits the most pronounced conductance change and clearest gate-tunable response, suggesting enhanced sensitivity without compromising device stability. Selectivity is also evaluated against common breath VOCs (e.g., acetone, ethanol), and a noise-aware procedure is outlined to estimate the detection limit from simulated transfer curves. Overall, the findings indicate that well-matched all-carbon contacts, combined with biasing near 1.4 V, can amplify the hexanal signature in SWCNT-FETs—supporting the feasibility of a compact, non-invasive breath test for early liver cancer screening.

روابط وملفات

التعريف والنوع

رقم الوثيقة

04dbdcdf-d978-4f58-83c0-e3ef0f9ed347

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1084784_2.pdf

بيانات النشر

ترجمة العنوان

الكشف عن المؤشرات الحيوية لسرطان الكبد في هواء الزفير باستخدام مستشعر نانوي قائم على ترنزستور تأثير المجال لأنابيب الكربون النانوية أحادية الجدار: دراسة محاكاة باستخدام برنامج QuantumATK

ألقاب المؤلفين

[{"name_ar":"Falah Awwad","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Mohamed Mohieb Rashdan ","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

BREATH-BASED DETECTION OF LIVER CANCER BIOMARKERS USING AN SWCNT-FET NANO-BIOSENSOR: QUANTUMATK

المحتوى والصفحات

عدد الصفحات

0

كلمات الباحثين

SWCNT-FET, hexanal, liver cancer, breath analysis, VOC sensor, NEGF, Extended Hückel, QuantumATK, metallic SWNT electrodes, transmission spectrum.

إشراف وإعداد

الإشراف

Falah Awwad

الإعداد

Mohamed Mohieb Rashdan

الاقتباسات الببليوغرافية