Evaluation des propriétés biopharmacologiques, standardisation chimique et valorisation des agroressources fonctionnelles cas de Vitis vinifera, Punica granatum, Citrus aurantium et Opuntia ficus-indica.

الموضوعات

علوم بحتة وطبيعية

الملخص

The present work was based on the valorization of agroresources of four fruits grown locallyin Algeria; Vitis vinifera, Punica granatum, Citrus aurantium and Opuntia ficus-indica by thedetermination of their molecular characterizations and biological activities.The hydroalcoholic extracts of the selected fruits were evaluated for their antioxidant,analgesic, healing and antihyperlipidemic activities as well as their toxic potential.A chromatographic analysis by HPLC-DAD-ESI/MS was performed and supplemented by aquantitative evaluation of the total phenols, flavonoïds, flavonols, condensed andhydrolysable tannins. The results of the quantitative analysis show that the levels of the ofVitis vinifera fruit extract on phenolic compounds are significantly higher than those of otherfruits. The results of the HPLC-DAD-ESI/MS analysis revealed a chromatographic profiledominated by a bargaptene (coumarin) for the extract of Punica granatum and by the phenolicacids and flavonoïds for the other extracts.The antioxidant activity (DPPH•, ABTS•+, FRAP, ORAC, TBARS, NO•) evaluated in vitroshowed that the antioxidant potential of the Vitis vinifera extract is the most importantcompared to the other extracts. The Punica granatum extract has also a potential antioxidantactivity but it remains less important than that of the previous species.The Vitis vinifera and Punica granatum extracts showed an analgesic effect on the three tests(torsion, hot plate and tail immersion), of which the potential to reduce the pain wasstatistically comparable in both extracts and was most evident in the torsion test. On the otherhand, the results of the evaluation of the healing activity in the rabbits showed that the Punicagranatum extract and at lesser degree that of Vitis vinifera accelerate the process of healingof excisional wounds and burns compared to the control, and was even superior to that ofcommercial healing cream (Cicatryl®). The results of the antihyperlipidemic activity showedthat the Vitis vinifera and Punica granatum extracts normalized the lipidemic profile in micemade hyperlipidemic compared to the control. Finally, the results of the acute toxicity in micedemonstrated that the Vitis vinifera and Punica granatum extracts are free of any signs oftoxicity at the maximum dose prescribed.

روابط وملفات

التعريف والنوع

رقم الوثيقة

04d8f7fc-f2d0-4aab-be39-c03bf236fe19

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

pdf text

أسماء الملفات

796068_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Abdelmalik Belkhiri","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Nadia Zeghad ep Bououden","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

French

المصدر والدورية

اسم المصدر

Evaluation des propriétés biopharmacologiques, standardisation chimique et valorisation des agroressources fonctionnelles cas de Vitis vinifera, Punica granatum, Citrus aurantium et Opuntia ficus-indica.

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Nadia Zeghad ep Bououden

الإعداد

Abdelmalik Belkhiri

الاقتباسات الببليوغرافية