Effect of vitamin D supplementation on Age-Related Macular Degeneration in the Gaza strip

الموضوعات

علوم بحتة وطبيعية

الملخص

Background: Age Related Macular Degeneration (AMD) is a degenerative disorder considered as the main cause of blindness among ageing populations, AMD advances so slowly that vision loss may take a long time to occur. In others, the disease progresses faster and may lead to a loss of vision. There is a strong biological rationale supporting a role of inflammation in the development and progression of AMD. Objective: To study the effect of Vitamin D supplementation on AMD by reduction of inflammation markers and amyloid beta levels in blood. Method: A randomized controlled clinical trial was conducted with forty-one patients with AMD had been matched, randomly allocated into two groups by simple randomization method and met the inclusion and exclusion criteria. Twenty-one patients were in intervention group who received vitamin D supplementation and twenty patients were in control group that did not receive any supplements and continued on their routine diet. Results: when comparing the test results in the control group pre and post intervention period Amyloid beta, Tumor Necrosis Factor (TNF), Interleukin 6 (IL6), Interleukin 1 (IL1), high sensitivity C Reactive Protein (hs-CRP), Lymph cells and Monocyte cells showed non-significant increase (p=0.223, 0.474, 0.097, 0.166, 0.156, 0.058, 0.084) respectively, but their White Blood Cells (WBC) counts reported significant decrease (p=0.006). In intervention group patients who received three month of vitamin D supplementation, their test results of Amyloid beta pre and post intervention reported significant increase (p=0.044), while TNF, IL6, IL1, hs-CRP, WBC and lymph cells tests revealed non-significant increase (p= 0.243, 0.065, 0.502, 0.644, 0.506, 0.174) respectively, surprisingly their monocyte cells test result showed significant decrease (p=0.022). Conclusion: Our findings indicated that none provides proof for associations between AMD and vitamin D supplementation. The association between vitamin D and AMD requires additional investigations in a large population studies, to elucidate whether vitamin D supplements has a beneficial effect in AMD progressing. Key words: AMD, inflammation, amyloid beta, vitamin D.

روابط وملفات

التعريف والنوع

رقم الوثيقة

0423ae61-302d-48df-833c-97b8dcafc96e

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

2103528_1.pdf

بيانات النشر

ترجمة العنوان

تأثير مكملات فيتامين (د) على مرض الاعتلال الشبكي الشيخوخي في قطاع غزة

ألقاب المؤلفين

[{"name_ar":"إيهاب المصري","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"إيهاب ناصر ","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"نور عبدالله رجب السراج","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Effect of vitamin D supplementation on Age-Related Macular Degeneration in the Gaza strip

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

إيهاب المصري, إيهاب ناصر

الإعداد

نور عبدالله رجب السراج

الاقتباسات الببليوغرافية