Studiing the effect of exerciise on the expressiion of iinduciiblle niitriic oxiide synthase and heat shock proteiin 70 iin the braiins of miice wiith iinduced Parkiinson`s diisease

الموضوعات

علوم بحتة وطبيعية

الملخص

Parkinson disease is a common neurodegenerative disease. Deficiency ofdopamine is thought to be responsible for development of Parkinson Disease.Exercise training has been associated with improvements in patients withParkinson Disease. The objective of the present study is to explore the effect ofexercise training on the expression of HSP70 and iNOS in brains of mice withinduced Parkinson Disease.Forty albino mice were selected and assigned into four groups: Sedentarycontrol (SC, N=10), exercised control (EC, N=10), Parkinson Disease (PD,N=10) and exercised Parkinson Disease (EPD, N=10). MPTP protocol was usedto induce Parkinson Disease by injections of 10 doses of MPTP (25 mg/kg) andprobenecid (250 mg/kg) over 5 weeks. After the protocols treadmill exercisetraining had been finished, samples from the brain tissues were assessed byimmunohistochemistry to examine the expression of HSP70 in the four groups ofanimals.The results of the present study showed that the expression of HSP70 wasreduced in the brain of mice with Parkinson Disease significantly (P 0.05) in EPD compared with PD.Although the increased expression of HSP70 in exercised ParkinsonDisease was not significant, it has a potential role in improved the status of micewith Parkinson Disease and it may have a potential therapeutic role.The data of the present study also showed significant expression of iNOSin brainsof rats with induced Parkinson Disease compared with control group (P0.000) compared with control group, and this expression was significantlydecreased in exercised group (P 0.000).

روابط وملفات

التعريف والنوع

رقم الوثيقة

03da5c88-b38c-481b-a8d3-09c61bcb3cf0

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

ماستر (LMD)

نوع الملف

pdf text

أسماء الملفات

215445_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Fatima Laiche","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Noureddine Djebli ","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

Studiing the effect of exerciise on the expressiion of iinduciiblle niitriic oxiide synthase and heat shock proteiin 70 iin the braiins of miice wiith iinduced Parkiinson`s diisease

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Noureddine Djebli

الإعداد

Fatima Laiche

الاقتباسات الببليوغرافية