Frequency of Abo, Rhesus Phenotypes and Most Probable Genotypes and the Type of RHD Negative Variants among UAE Nationals in Al Ain District

الموضوعات

علوم بحتة وطبيعية

الملخص

Knowledge of the frequencies and the phenotypes of ABO and rhesus system is very important for blood bank and transfusion services policies. The objective of this study was to determine the frequency of ABO, Rhesus phenotype and most probable genotypes in Al Ain area (UAE). The studied group consisted of 500 locals of both gender from different age groups (17-58 years old). ABO and Rh-hr phenotype reactivity were determined using conventional tube method and gel technology, molecular techniques were also applied. Our study shows the distribution of ABO phenotypes was as follows: 0= 56%, A= 26.2%, B= 14.2% and AB= 3.6%. The distribution of Rh antigens was as follows: D= 90.4 %, C= 76.2%, E= 27.2%, c= 71.6% and e= 97.8%. And the distribution of most probable genotypes was as follows: Rl r= 29.8%, R l R l = 28.4%, R l R2= 16.8%, rr= 8.4%, R2 r= 8.2%, R o 1'=5%, R2 R2= 2.2%, and r'r= 1.2%. Our study showed that the most frequent antigen amongst five major antigens of Rh system was RhD while the least common was E antigen. We developed an innovative method that combines molecular analysis and serological testing of Rh genes to be applied in blood bank environment as it is considered as a first study done in the area. This approach could improve patient care and transfusion outcomes by reducing alloimmunization. The challenge lies in integrating such testing into blood bank environment, standardizing methods, obtaining Food and Drug Administration approval for labeling donor units, and enhancing information systems to incorporate and use this new information effectively.

روابط وملفات

التعريف والنوع

رقم الوثيقة

036f4bb4-d62a-4246-bd46-b921885c0cb9

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

7014_1.pdf

بيانات النشر

ترجمة العنوان

تحديد نسبة توزع الزمر الدموية وعامل التخثر من خلال الانماط الظاهرية والجينية الاكثر احتمالا بين سكان منطقة العين

ألقاب المؤلفين

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اللغة

English

المصدر والدورية

اسم المصدر

Frequency of Abo, Rhesus Phenotypes and Most Probable Genotypes and the Type of RHD Negative Variants among UAE Nationals in Al Ain District

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

راشد الحمادي

الإعداد

مريم حماد زاهر سعيد المقبلي

الاقتباسات الببليوغرافية