The Effect of Dexmedetomidine and DEX-Ketamine on adult Alectoris Chukar Subspecies (Kurdestanica) and Their Reversal by Atipamizole

الموضوعات

طب

الملخص

Surgical intervention and painful disease conditions frequently apply to avian patients presented to veterinary clinics, and anesthesia and analgesia are essential parts of the daily routine associated with avian veterinary practices. However, avian anesthetic procedures differ primarily from mammal medicine because of different physiological compositions and anatomical structures. Birds are very sensitive animals, and any mismanagement results in a crisis that can lead to immediate shock and death. Unfortunately, few anesthetic and sedative protocols exist for wild birds, including partridges. Dexmedetomidine (DEX) is a new drug not used in partridge species. Accordingly, this study was designed to examine DEX's sedative and analgesic doses and side effects in Chukar partridges. The study also aimed to determine DEX's sedative and anesthetic activities when combined with ketamine (KET) in Chukar birds and determined the effectiveness of atipamezole (ATEP) in reversing DEX's sedative and analgesic effects. Twenty-seven adult Chukars of both sexes, aged 8–12 months, were collected from the rural areas around Penjwin district in Iraqi Kurdistan. The partridges were adapted for living in a specially designed wooden cage for about two weeks. The birds were randomly divided into subgroups to assess the sedative dose of DEX. Alterations in respiratory rate (RR), heart rate (HR), cloacal temperature (CT), and blood biochemistry were investigated before and after every experiment, and analgesia and anesthesia pain reflexes were assessed using many different methods, such as the hot water test. Lastly, anesthesia was assessed via surgical incision, and induction and recovery times with and without ATEP were recorded. DEX administration induced significant changes in HR, RR, and CT, which decreased significantly after DEX and KET administration, while after giving ATEP, the HR and RR increased sharply, except CT, which decreased gradually. Biochemical parameters also showed slight changes, especially in decreasing total protein, even though creatinine, glucose, and blood urea nitrogen were increased. The median effective concentration of DEX to sedate Chukars was 179.6 ± 11.3 μg/kg. A combination of DEX (200 μg/kg) and KET (20 mg/kg) provided a smooth anesthesia induction in these birds. All partridges recovered from sedation and anesthesia without complications and were released into their natural habitats after the experiments. The results demonstrated that DEX could be used in practice as a sedative in chukar partridges with a wide margin of safety. These findings ascertained that the DEX and KET anesthetic combination caused some definite biochemical changes in Chukar partridges, which veterinarians should carefully judge during surgical interventions to avoid anesthesia-related risks and complications. To our knowledge, there is no published report describing the anesthetic outcome of DEX, especially in combination with KET in Chukar partridge. The results of this study provide wildlife rescue teams, veterinarians, and local animal health-related authorities with information about introducing the new drug DEX as a pre-anesthetic agent in Chukar partridge and comparing its analgesic activities with KET. Accordingly, better control programs can be designed for monitoring avian species under sedation and anesthesia. Furthermore, veterinarians can choose the best antidote among the currently available drugs. In conclusion, this study revealed that DEX, an α2-adrenoceptor agonist, is an appropriate adjunct to the current anesthetic agents. This latest α2-receptor agonist is highly effective with stress-reducing, analgesic, and excellent sedative properties. It has a rapid inception and a comparatively short interval of action, which makes it a suitable agent in veterinary medicine. Correspondingly, when combined with KET, it will produce balanced anesthesia that can be reversed straight forwardly by ATEP.

روابط وملفات

التعريف والنوع

رقم الوثيقة

02ba2db1-e3d6-4f2a-a906-8ec98cce5460

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf image

أسماء الملفات

02ba2db1-e3d6-4f2a-a906-8ec98cce5460_1.pdf

بيانات النشر

ترجمة العنوان

تأثیر دیكسمیدیتومیدین وكيتامين على سلالات القبج الكردية البالغة (كوردستانكا) وانعكاسها بواسطة الأتيباميزول

ألقاب المؤلفين

[{"name_ar":"بافل عمر قادر","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"بھجت طيفور عباس","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"دياري هيوا عثمان","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

The Effect of Dexmedetomidine and DEX-Ketamine on adult Alectoris Chukar Subspecies (Kurdestanica) and Their Reversal by Atipamizole

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

بھجت طيفور عباس, دياري هيوا عثمان

الإعداد

بافل عمر قادر

الاقتباسات الببليوغرافية