Renal Parameters and Their Associations with Clinical Severity Score among Adult Sudanese with Sickle Cell Anemia

الموضوعات

طب

الملخص

:Background: As there is a global increase in survival of people living withSickle Cell Anaemia (SCA); the prevalence of chronic complications includingnephropathy is increased, so early identification, detection and management ofthese complications is mandatory.Objectives: This study aimed to investigate the estimated Glomerular FiltrationRate (eGFR), proteinuria and serum uric acid as markers of renal involvementin Sudanese adults with Sickle Cell Anaemia (SCA) and the relationshipbetween these parameters and clinical severity score of SCA.Methods: This was hospital based, cross-sectional study. 55 participantsSudanese (32 Sickle cell anaemia group and 23 normal Hb A control group)were included in this study. Informed consent was obtained, Medical historywas obtained and clinical examination was performed, blood and urine sampleswere taken from each participant. Severity score was calculated for sickle cellanaemia patients and Glomerular Filtration Rate (eGFR) was estimated, Uricacid level and urine for protein/creatinine ratio, were measured for eachparticipant.Results: Hyper-filtration was manifested in 75% of Sickle cell anaemia group.Proteinuria (Protein/Creatinine Ratio) was significantly higher (P value > 0.001)in sickle cell anaemia group and significant proteinuria was detected in 12.5%among sickle cell anaemia group. Hyperuricemia only found in 6.3% of sicklecell group. The mean arterial blood pressure (MAP) was significantly lower (Pvalue 0.03) in sickle cell group. There was no association between the severityscore and renal manifestations in the sickle cell anaemia group.Conclusions: Hyper-filtration and proteinuria were the most prevalent renalmanifestations in the Sickle group. Higher levels of uric acid and lower bloodpressure were observed in sickle patients when compared to controls.Recommendations: We recommend further studies to determine predictors ofthe renal disease and early detection and appropriate management ofproteinuria, hyperuricemia in patients with sickle cell anaemia. We suggestdevelopment of modified severity score that include renal complications.Keywords: sickle cell anaemia, renal manifestations, glomerular filtrationrate (GFR), uric acid.

روابط وملفات

التعريف والنوع

رقم الوثيقة

02b57014-7395-4c36-8cc2-57aa7bb18d5f

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf image

أسماء الملفات

02b57014-7395-4c36-8cc2-57aa7bb18d5f_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Lamis AbdelGadir Kaddam","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Mohammed Abdelazim Osman Suliman","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Renal Parameters and Their Associations with Clinical Severity Score among Adult Sudanese with Sickle Cell Anemia

المحتوى والصفحات

عدد الصفحات

0

إشراف وإعداد

الإشراف

Lamis AbdelGadir Kaddam

الإعداد

Mohammed Abdelazim Osman Suliman

الاقتباسات الببليوغرافية