Comparaison de la curiethérapie LDR versus HDR: étude dosimétrique et radiobiologique en utilisant la plateforme GATE - application à la curiethérapie oculaire

الموضوعات

علوم بحتة وطبيعية

الملخص

L’objectif de cette thèse est de valider GATE pour la dosimétrie des traitements de curiethérapie. Nous nous sommes intéressés aussi à la comparaison dosimétriques et radiobiologiques des deux types de curiethérapies (LDR vs HDR) pour une tumeur uvéale réelle en utilisant GATE. Plusieurs paramètres dosimétriques ont été étudiés selon l’ICRU-72 et NCS-14. Afin de valider GATE comme un TPS, nous avons étudié ces paramètres dosimétriques recommandés par le TG-43. Les résultats obtenus montrent une bonne concordance entre GATE et les études prises comme référence, en particulier pour les applicateurs dont la forme concave.

روابط وملفات

التعريف والنوع

رقم الوثيقة

01da9a2d-d0e8-4404-85ba-d4b469c4d1cf

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل دكتوراة

نوع الملف

word

أسماء الملفات

1370927_1.docx, 1370927_2.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Mostafa Laoues","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Rachid Khelifi","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

French

المصدر والدورية

اسم المصدر

Comparaison de la curiethérapie LDR versus HDR: étude dosimétrique et radiobiologique en utilisant la plateforme GATE - application à la curiethérapie oculaire

المحتوى والصفحات

عدد الصفحات

0

ترجمة الملخص

Treatment planning in radiotherapy requires accurate calculation of the dose delivered to the tumor and good knowledge of the dose in neighboring organs. This calculation usually carried out by the treatment planning systems (TPS). The idea is to use the calculations of the GATE Monte-Carlo simulation platform based on the GEANT4 code in the daily treatment of cancer with radiation to compete with the existing TPS for the purpose of performing dosimetric and radio biological reliably and quickly calculations forspecific treatments.The objective of this thesis is to validate GATE/GEANT 4 for electrons dosimetry applications, two studies have been carried out in parallel: the validation of the GATE platform for treatments dosimetry of ocular brachytherapy with low dose rate (LDR) and high dose rate (HDR) using 106Ru/106Rh and 90Sr/90Y ophthalmic applicators, respectively. GATE has been validated for calculation of dose point kernels of mono-energetic and poly-energetic electrons and has been compared with the results of other Monte Carlo studies.Different versions of GEANT4 library packages were used for the comparisons (5.2, 6.2, 7.0 and 9.4). A detailed study was carried out on the influence of the implementation of multiple scattering during the transport of electrons on the different versions of GEANT4 and on the different codes.Compared to other Monte Carlo and measurements, the results of LDR and HDR ocular brachytherapy treatments simulations show good agreement. We were also interested to dosimetrical and radiobiological comparison of the two types of brachytherapy (LDR vs HDR) for a real uveal tumor located in a heterogeneous eye phantom simulated with GATE.For this, two models of ruthenium 106 ophthalmic applicator used in LDR brachytherapy (CCB 'flat' and CCB 'concave' of BEBIG) and two other Strontium90 applicators used in HDR ocular brachytherapy (SIA.20 'flat' and SIA.6 'concave' of Amersham) were simulated. Several dosimetric parameters have been studied in accordance with the recommendations of the report N°72 of the International Commission on Radiation Units and Measurements (ICRU-72) and the report N°14 of the Netherlands Commission on Radiation Dosimetry (NCS-Nederlandse Commissie voor Stralings dosimetrie).The obtained results mainly for the HDR applicators show a good agreement between GATE and reference studies. The use of GATE in treatment planning requires a better definition of the deposited doses in the tumor and the organs at risk (OAR). In order to validate GATE as a TPS, and as this latter is based on the dosimetric characteristics recommended by Task Group N°43 of the AAPM(American Association of Physicists in Medicine), we have studied these parameters. The results obtained show a good agreement between GATE and the reference studies recommended by the AAPM, especially for concave applicators. The ultimate goal is to make GATE a reliable tool use in clinical settings, in particular for ocular brachytherapy dosimetry with a good OAR protection.

كلمات الباحثين

curiethérapie oculaire, dosimétrie, dosimetry, GATE,, GEANT4, Monte Carlo simulations, ocular brachytherapy, points kernels, radiobiologie, radiobiology, Ruthenium 106, Ruthénium106, simulations Monte Carlo, Srontium 90

إشراف وإعداد

الإشراف

Rachid Khelifi

الإعداد

Mostafa Laoues

الاقتباسات الببليوغرافية