Statistical study on the prevalence of the use of the Ephedra alata in the El-Oued region and Study of its protective effect on Bleomycin induced toxicity and oxidative stress in Albinos rats

الموضوعات

علوم تطبيقية وتكنولوجية

الملخص

The objective of this work was to do a statistical study on the prevalence of the use of Ephedra alata in the El-Oued region and study the effect of aqueous extract of Ephedra alata L. for protection of toxicity induced by Bleomycin in rats. For the statistical study, 50 persons interviewed were chosen; some of the information related to the interrogators and others about the plant were adopted in the survey. For the in-vitro study, qualitative and quantitative phytochemical compounds and biological activities were assessed on the Ephedra alata L. aqueous extract. For the in-vivo study, twenty female albino Wistar rats were divided into 4 groups (n = 5); Control group, E. alata group (AEEA), Bleomycin group (BLM), and rats co-treated with BLM and AEEA group (BLM + AEEA). BLM induced toxicity using an intraperitoneally single dose of 10 U/kg. E. alata was treated orally at a dose of 200 mg/kg/day for 30 days. Various hematological, biochemical, and oxidative stress markers were estimated. Histopathology of liver, lungs, and kidneys tissues was observed. The results obtained show that in traditional medicine, men and people between the ages of 31 and 60 years are more interested in using Ephedra alata. The aerial part of the plant is mostly used by the decoction method to treat cancerous diseases and diabetes. Results of the in-vitro phytochemical results revealed that E. alata contains most of the active compounds, especially flavonoids of various kinds with high antioxidant and anti-inflammatory activity. Results of the in-vivo rats study show that BLM-treated rats induced alterations in hematological and biochemical parameters compared to the control group. Also, BLM-treated rats induced oxidative stress and histological alterations in lungs, liver, and kidney cells compared to control rats. Co-treatment of BLM with AEEA partially reversed all of the previous parameters, without any negative effect for the use of the plant in healthy rats. This study indicated that the anti-inflammatory and antioxidant properties of the leaves' aqueous extract of Ephedra alata allowed their use to protect organs from the side effects of drugs or from the destructive effects of various diseases. Other studies are necessary to delve into these findings and to determine the factors responsible for the beneficial effects of the plant.

روابط وملفات

التعريف والنوع

رقم الوثيقة

01ce7199-6981-4437-a970-85e056db335e

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

ماستر (LMD)

نوع الملف

pdf text

أسماء الملفات

1049682_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Meriem Chadou","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Ouafa Zouari Ahmed ","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"Samir Derouiche","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Wissal Ben Ghalia","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

Statistical study on the prevalence of the use of the Ephedra alata in the El-Oued region and Study of its protective effect on Bleomycin induced toxicity and oxidative stress in Albinos rats

المحتوى والصفحات

عدد الصفحات

0

كلمات الباحثين

Ephedra alata L, Bloemycin, side effect , lungs, polyphenols, oxidative stress, Wistar rats.العلندة

إشراف وإعداد

الإشراف

Samir Derouiche

الإعداد

Meriem Chadou, Ouafa Zouari Ahmed , Wissal Ben Ghalia

الاقتباسات الببليوغرافية