The mechanistic aspects of the anti-inflammatory activity of Lavandula stoechas

الموضوعات

علوم بحتة وطبيعية

الملخص

Inflammation is a defensive mechanism against various harmful stimuli, which involves both the innate and the acquired immune responses.This response includes vascular and cellular events which are highly coordinated by different inflammatory mediators. It is aimed to repair andrestore the normal homeostasis of the injured tissue. However, persistent or uncontrolled inflammation can lead to the development of chronicinflammation which may act as the central executor in the pathogenesis of many inflammatory diseases. Taking into consideration the adverseside effects of synthetic anti-inflammatory drugs, the search for new anti-inflammatory agents from herbal sources is desirable.The recent growing interest towards natural remedies and medicinal plant-derived products in alternative therapies has shed some light onlavender including its different species such as our plant of interest, Lavandula stoechas which could serve as a potential source for antiinflammatorybioactive molecules that could be further used for drug development.The aim of this study was to evaluate the anti-inflammatory activity as well as the underlying molecular mechanisms of action of somebioactive molecules found in Lavandula stoechas essential oils and extracts.Results from published experimental and clinical studies demonstrated the anti-inflammatory properties of Lavandula stoechas which wasmainly due to its richness of bioactive compounds such as 1,8-cineole, camphor, luteolin, and apigenin. Additionally, these findings proposedthat the anti-inflammatory mechanism of action of these phytochemicals is mediated through the modulation of various pro and antiinflammatorymediators such as interleukins, tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), nitric oxide (NO), as well asprostaglandins and leukotrienes. Additionally, they induce the inhibition of arachidonic acid (AA) metabolism, cyclooxygenase-2 (COX-2),lipooxygenase (LOX), inducible nitric oxide (iNOS), and various transcription factors implied in the expression of pro-inflammatory genes.Finally, the identified components from Lavandula stoechas could be incorporated into future novel bioactive anti-inflammatory formulationsand in the exploitation of targeted therapies used for the treatment of inflammatory diseases. However, further studies need to be undertaken

روابط وملفات

التعريف والنوع

رقم الوثيقة

0158daaf-c599-4f9e-aec0-88de05f646fc

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

ماستر (LMD)

نوع الملف

pdf text

أسماء الملفات

2185643_1.pdf

بيانات النشر

ألقاب المؤلفين

[{"name_ar":"Asma Cherbal","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"Imane Attaf","title_ar":"اعداد","title_en":"Preparation"}]

اللغة

English

المصدر والدورية

اسم المصدر

The mechanistic aspects of the anti-inflammatory activity of Lavandula stoechas

المحتوى والصفحات

عدد الصفحات

0

كلمات الباحثين

Inflammation Lavandula stoechas; Secondary metabolites; Terpenes Flavonoids 1,8-cineole Camphor Luteolin Apigenin Anti-inflammatory activity

إشراف وإعداد

الإشراف

Asma Cherbal

الإعداد

Imane Attaf

الاقتباسات الببليوغرافية