تحضير وتقييم في الزجاج لجسيمات ميكرومترية بأساس من الألبومين وغيره من البلمرات كحوامل لبعض أدوية الوهن العضلي

الموضوعات

طب

روابط وملفات

التعريف والنوع

رقم الوثيقة

00b68506-aeb3-47b4-93c0-201e4a480397

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1963848_1.pdf

بيانات النشر

ترجمة العنوان

Preparation and in vitro Evaluation of Microparticles based on Albumin and Other Polymers as Carriers for Some Myasthenia Drugs

ألقاب المؤلفين

[{"name_ar":"لارا محي الدين القبيطري","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"محمد عبد الرؤوف عثمان","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

Arabic

المصدر والدورية

اسم المصدر

تحضير وتقييم في الزجاج لجسيمات ميكرومترية بأساس من الألبومين وغيره من البلمرات كحوامل لبعض أدوية الوهن العضلي

المحتوى والصفحات

عدد الصفحات

166

ترجمة الملخص

Purpose :My asthenia gravis is an autoimmune disorder characterized by defective neuromuscular transmission and consequent muscular weakness. It is caused by the formation of autoantibodies to elements of the neuromuscular junction. Neostigmine methylsulfate (NS) is an Acety lcholinesterase inhibitor and has a short half-life (about one hour), extended release hydrogel systems containing microparticles based on Bovine Serum Albumin (BSA) and other polymers as carriers for NS were developed as an alternative to the conventional dosage forms to enhance patient compliance. Methods: Microparticles were prepared using coacervation technique and formulated into hydrogel systems, with two different concentrations based on poloxamer 407 as a gelling agent. An analytical method was developed to titrate NMS in hydrogel systems byU.V. spectro photometry. Physical characteristics, in-vitro drug release, kinetic models and release mechanisms of all the hydrogel systems were then evaluated. The drug-excipients physical interactions werestudied usingFTIR, differential scanning calorimetry, and X-ray powder diffractometry .Results:Formulas which contained (Acacia+ BSA), (Pectin+ BSA), (Sodium alginate+ BSA) with concentrations of 0.6 mg/ml poloxamer 407, were able to extend the drug release up to (24) hours. The preparation method which combined coacervation and spray drying hada good effect on retarding the drug release. Conclusion:In vitro release studies showed that the prepared hydrogel systems are promising drug delivery systems, in Comparision with the conventional forms.

كلمات الباحثين

coacervation, hydrogel, microparticles, myasthenia gravis, spray drying, sustained release, النقوصر, الوهن العضلي, جسيمات ميكرومترية, هلامات مائية

إشراف وإعداد

الإشراف

محمد عبد الرؤوف عثمان

الإعداد

لارا محي الدين القبيطري

الاقتباسات الببليوغرافية