effectiveness of glucosamine treatment on the modulation of some immunological parameters in patients with knee osteoarthritis

الموضوعات

طب

الملخص

Osteoarthritis is the most common condition to affect human joints and a frequent cause of disability. Aim of the study: The aim of this study was to determine the effect of oral glucosamine (1000–1500 mg/day) treatment prescribed to knee OA patients on serum C3, which represents the complement system as it plays an important role in all three pathways of complement system activation, and on some cytokines such as IFN-γ, which represents the function of Th-1, IL-4, which represents the function of Th-2, and IL-6, which represents the acute inflammatory phase protein. In addition, the study aims to evaluate the effect of the duration of glucosamine treatment on these parameters, as well as to know if glucosamine treatment had an effect on a grade of osteoarthritis more than another. Patients, Materials, and Methods: This study included 40 patients who had different grading of knee osteoarthritis on regular oral glucosamine (1000–1500 mg/day) for different durations of administration. Twenty patients had osteoarthritis on acetaminophen only without glucosamine treatment (1st control) and 20 healthy control people (2nd control). Blood samples were taken from all groups, and serum values of C3 were measured by nephelometric method using an automated machine (MININEPH), while serum values of IFN-γ, IL-4, and IL-6 were measured by ELISA technique. Statistical analysis was done using the SPSS computing program at (p<0.05) level of significance. Results: The concentration of C3 in serum of patients with OA on oral glucosamine was significantly lower (p<0.05) than that of OA patients without glucosamine, while there was no significant difference as compared with healthy control people. The concentration of IFN-γ, IL-4, IL-6 in OA patients on glucosamine was significantly lower (p<0.05) than that of both OA patients without glucosamine treatment and the healthy control group. However, it was significantly higher (p<0.05) in OA without glucosamine treatment as compared with the healthy group. Within the first three months of glucosamine treatment, serum C3 and IFN-γ were significantly higher (p<0.05) than that of the second, third, and fourth three months; in addition, the second three months were significantly higher (p<0.05) than that of the third and fourth three months. There was no significant difference between the third and fourth three months of glucosamine treatment. Within the first three months of glucosamine treatment in OA patients, serum concentration of both IL-4 and IL-6 was significantly higher (p<0.05) than that of the second, third, and fourth three months of treatment. There was no significant difference between the second, third, and fourth three months of glucosamine treatment. According to the grading of OA, the results showed that there were no significant differences in all parameters between the gradings of OA. Conclusion: Glucosamine played an important role in the modulation of inflammatory processes as reflected on the complement system, since glucosamine was able to normalize serum C3 concentration in OA patients. This normalization can be achieved nearly after six months of glucosamine treatment. Furthermore, glucosamine treatment can also reduce the pro-inflammatory cytokines, mainly IFN-γ, IL-4, and IL-6 levels in OA patients even below that of the healthy control group. The reduction of IFN-γ was achieved nearly after six months. In addition, the normalization of both IL-4 and IL-6 was achieved after three months of glucosamine treatment. However, glucosamine treatment was not significantly influenced by OA grading.

روابط وملفات

التعريف والنوع

رقم الوثيقة

00a814d7-3435-43a1-be03-4bddff26f435

رقم العقد

0

نوع الوسائط

Crawler

نوع المحتوى

الرسائل العلمية

صيغة المصدر

رسائل ماجيستير

نوع الملف

pdf text

أسماء الملفات

1000713_1.pdf

بيانات النشر

ترجمة العنوان

فعالية استخدام الكلوكوزامين على تحوير بعض المتغيرات المناعية لمرضى التهاب مفصل الركبة الضموري

ألقاب المؤلفين

[{"name_ar":"رسل علي كاظم","title_ar":"اعداد","title_en":"Preparation"},{"name_ar":"صباح نعمة الثامر","title_ar":"اشراف","title_en":"Supervision"},{"name_ar":"علي محمد حسين القزاز","title_ar":"اشراف","title_en":"Supervision"}]

اللغة

English

المصدر والدورية

اسم المصدر

effectiveness of glucosamine treatment on the modulation of some immunological parameters in patients with knee osteoarthritis

المحتوى والصفحات

عدد الصفحات

0

ترجمة الملخص

التهاب مفصل الركبة الضموري هو من الإمراض الشائعة التي توثر على مفاصل جسم الإنسان ويعتبر سبب من أسباب الاعتلال.الهدف من هذه الدراسة : كان الهدف من هذه الدراسة هو تحديد تأثير الجلوكوزامين الذي يعطى عن طريق الفم و الذي يوصف للمرضى الذين يعانون من التهاب مفصل الركبة الضموري على تركيز C3 المتمم الثالت لمصل الدم والتي تمثل نظام المتممات لأن C3 تلعب دورا أساسيا في جميع المسارات الثلاثة لنظام المتممات ، وكذلك دراسة لبعض السيتوكينات مثلIFN-γ التي تمثل وظيفة Th-1، IL-4 والتي تمثل وظيفة Th-2 و IL-6 التي تمثل المرحلة الحادة من البروتين، وإذا كان هناك تأثير في مدة تناول الكلوكوز امين على هذه المعايير، فضلا عن معرفة ما إذا كان أكثر الجلوكوزامين يؤثر على درجة معينه من درجات تصنيف التهاب مفصل الركبة الضموري أكثر من غيرها.المرضى والمواد وطرق العمل: شملت هذه الدراسة 40 مريضا يعانون التهاب مفصل الركبة الضموري ويتناولون و بشكل منتظم كلوكوزامين عن طريق الفم (1000ملغم-1500ملغم يوميا) بفترات مختلفة (الفترة الأولى من 1 إلى 3 أشهر والثانية من 3الى 6 أشهر والثالثة من 6 إلى 12 شهر والرابعة 12 إلى 24 شهر) و 20 مرضى التهاب مفصل الركبة الضموري الذين كانوا على علاج الأسيتامينوفين فقط (500ملغم /3مرات يوميا) و 20 من الأشخاص أصحاء . وقد أخذت عينات دم من جميع الفئات وتم قياس تركيزC3 لمصل الدم بطريقة nephelometric وباستخدام الجهاز الآلي (MININEPH) وكذلك تم تقييس محتويات مصل الدم منγ IFN- ، IL - 4 و IL - 6 التي تم قياسها بتقنيةELISAتم التحليل الإحصائي باستخدام برنامج المبرمجSPSS واعتمدت قيمه p

كلمات الباحثين

Osteoarthritis, Glucosamine, Dietary supplements, Serum C3, Complement system, Cytokines, IFN-γ, IL-4, IL-6, OA grading

إشراف وإعداد

الإشراف

صباح نعمة الثامر, علي محمد حسين القزاز

الإعداد

رسل علي كاظم

الاقتباسات الببليوغرافية